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Early-Stage Progression of Breast Cancer

Uploader: Goltihn 4 years ago  
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Muller and colleagues developed a transgenic model bearing the unactivated form of neu fused to MMTV promoter [ ]. The cancer cells may spread to the lymph nodes behind the sternum. Immune cells also emerged as a promising target against breast cancer as both the innate and adaptive immune system is necessary for the design and development of immunotherapies in breast cancer. In the remainder of this section, we will provide a concise overview of normal breast stem cells and a review of recent evidence supporting the stem cell hypothesis as it relates to the origin of the different molecular subtypes of human breast cancer.

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