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A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells

Uploader: Mikalabar 4 years ago  
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Significant consideration has been given in finding plant-derived dietary agents, which can be developed as promising chemo preventives. The data provide evidence that synergistic antiproliferative effects of Chrysin and Silibinin are linked to the down-regulation of cyclin D1 and hTERT genes, and suggest that their combination may have therapeutic value in treatment of breast cancer. Thus, the target of the current review is to communicate its chemistry and bioavailability as well as anticancer potential of chrysin particularly referring to anti-inflammatory effect, antiapoptotic effects Figure 1. GraphPad Prism 6 was applied for statistical analysis. Experiments were conducted in accordance with institutional guidelines and approval of University of Toyama Animal Experimental Ethics Committee.

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